EXPERIMENTALLY-DERIVED FORMULA FOR COMPUTING SERUM OSMOLARITY IN PIGS
Keywords:
osmolarity, osmotic coefficient, chicken, linear regression analysisAbstract
The serum osmolarity mainly results from the inorganic ions and the small
molecules and only in small extent from the protein ions. In serum sodium,
potassium, chloride, bicarbonate, urea and glucose are the only components
present in high enough concentrations to individually affect the osmolality. There
are several different formulas for the calculation of human serum osmolarity. It has
not been demonstrated which of the formulas is most effective for serum from
various animal species. The goal of this study is to estimate the serum osmolarity in
pigs from the concentrations of the main electrolytes and the glucose and urea
content, and to establish the contribution of each osmotic component. Linear
regression analysis was carried out to determine the best predictors of serum
osmolarity in chickens. Two equations were also deduced for calculating serum
osmolarity using manual regression analysis: y = 1.8117 Na + Urea + Glucose +
26.05 and y = 1.8933 (Na+K) + Urea + Glucose + 4.93.
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