Verbascoside Affects Rabbit Mineral Profile Parameters

Authors

  • Martin Massányi Slovak University of Agriculture in Nitra, Faculty of Agrobiology and Food Resources, Department of Animal Husbandry, 949 76-Nitra, Tr. A. Hlinku 2, Slovak Republic
  • Nikola Knížatová Slovak University of Agriculture, Faculty of Biotechnology and Food Sciences, Department of Animal Physiology, 949 76-Nitra, Trieda Andreja Hlinku 2, Slovak Republic
  • Francesco Vizzarri University of Bari Aldo Moro, Department of Agricultural and Environmental Sciences, 70126-Bari, Italy
  • Ľubomír Ondruška National Agricultural and Food Centre Institute, Research Institute for Animal Production, Department of Small Farm Animals, 951 41-Lužianky, Hlohovecká 2, Slovakia, Slovak Republic
  • Grzegorz Formicki Pedagogical University of Kraków, Institute of Biology, Faculty of Exact and Natural Sciences, Department of Physiology, 30 084-Kraków, Podchorazych 2, Poland
  • Marko Halo Jr. Slovak University of Agriculture, Faculty of Biotechnology and Food Sciences, Department of Animal Physiology, 949 76-Nitra, Trieda Andreja Hlinku 2, Slovak Republic
  • Marko Halo Slovak University of Agriculture in Nitra, Faculty of Agrobiology and Food Resources, Department of Animal Husbandry, 949 76-Nitra, Tr. A. Hlinku 2, Slovak Republic
  • Peter Massányi Slovak University of Agriculture, Faculty of Biotechnology and Food Sciences, Department of Animal Physiology, 949 76-Nitra, Trieda Andreja Hlinku 2, Slovak Republic

Keywords:

blood, minerals, rabbit, verbascoside

Abstract

Verbascoside is a compound that belongs to a group of natural substances present in plants used in traditional medicine. It possesses multiple biological capabilities including anti-inflammatory, anti-bacterial and anti-tumour properties. Aim of the study was to evaluate the effect of verbascoside in two different concentrations (1 g/kg-LVB and 2 mg/kg-HVB in food mixture) on selected parameters of mineral profiles in rabbit blood. In our study the experiment lasted for 120 days and was executed on 45 New Zealand rabbit bucks. The average age of animals was 1 year±2 month. Rabbits were divided into three homogenous groups-first being the control group fed with a feed without any additives (control); LVB group with 5 mg/kg and HVB group supplemented with 10 mg/kg of verbascoside. In our experiment verbascoside did not cause significant changes in parameters of mineral profile in rabbit blood. Levels of sodium in control group were 135.22 mmol/l. The levels of Na in LVB reached 135.64 mmol/l and in HVB group 134.74 mmol/l. Potassium analysis shown concentrations in the range of 4.32 mmol/l-4.68 mmol/l with the lowest concentration in control group. The concentrations of Ca have remained almost unchanged compared to the control group with LVB group having the same concentration of 3.49 mmol/l and HVB group-3.48 mmol/l. Chlorides concentrations ranged from 106.05 mmol/l to 160.61 mmol/l and did not show any significant changes. Magnesium blood levels in our experiment did not show any significant changes either and ranged from 1.32 mmol/l to 1.34 mmol/l. We can state that verbascoside had no effect on mineral profile parameters in rabbit blood, but it has to be emphasized that its effect is more focused on different functions in various targeted organs as stated above.

References

Petrikovič, P., Chrenková, M., Produkčné efektívne a environmentálne tolerantné využitie nutričných zdrojov. Slovenské centrum poľnohospodárskeho výskumu- Výskumný ústav živočíšnej výroby, Nitra, 2008, 15-21.

Casamassima, D., Vizzarri, F., Palazzo, M., Massányi, P., Ondruška, Ľ., Corino, C., Effect of the addition of a verbascoside-based food supplement in feed, on some blood parameters and plasma oxidative status in white new zealand rabbits, Animal physiology 2011, 272–286.

Jimenez, C., Riguera, R., Phenylethanoid glycosides in plants: structure and biological activity, Natural Product. Reproduction, 1994, 12, 591–606.

Pennacchio, M., Syah, Y. M., Ghisalberti, E. L., Alexander, E., Cardioactive compounds from Eremophila species, Journal of Ethnopharmacology, 1996, 53, 21–27.

Feng, R., Lu, Y., Bowman, L. L., Inhibition of activator protein-1, NFkappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid, Journal of Biology and Chemistry, 2005, 280, 27888–27895.

Massányi, P., Toman, R., Valent, M., Čupka, P., Evaluation of selected parameters of a metabolic profile and levels of cadmium in reproductive organs of rabbits after an experimental administration, Acta Physiologica Hungarica, 1995, 83(3), 267–273.

Massányi, P., Slamečka, J., Lukáč, N., Capcarová, M., Mertin, D., Jurčík, R., Seasonal variations in the blood biochemistry of brown hare. In Medycyna weterynaryjna, 2009, 65(6), 389-393.

Cervera, C., Juncos, A., Martínez, E., Ródenas, L., BLAS, E., PascuaL, J. J., Effect of different feeding systems for young rabbit does on their 42 development and performance until first weaning: preliminary results. 9th World Rabbit Congress, June, Verona, Italy, 2008.

Ahamefule, F. O., Eduok, G. O., Usman, A., Amaefule, K. U., Obua, B. E., Oguike, S. A., Blood biochemistry and haematology of weaner rabbits fed sundried, ensiled and fermented cassava peel based diets, Pakistan Journal of Nutrition, 2006, 5(3), 248-253.

Hewitt, C. D., Innes, D. J., Savory, J., Wills, M. R., Normal biochemical and hematological values in New Zealand white rabbits, Clinical Chemistry, 35(8), 1989, 1777-1779.

Norata, G. D., Pellegatta, F., Catapano A. L., Peroxisome proliferators actived receptors and cardiovascular pathology, Italian Heart Journal, 2003, 4, 8–18.

Bursill, C., Roach, P., A green tea catechin extract upregulates the epatic low density lipoprotein receptor in rats, Lipids, 2007, 42, 621-627.

Palazzo, M.,Vizzarri, F., Cinone, M., Corino, C., Casamassima, D., Assessment of a natural dietary extract, titrated in phenylpropanoid glycosides, on blood parameters and plasma oxidative status in intensively reared Italian hares (Lepus corsicanus), Animal, 2011, 5(6), 844-850.

Diaz, A. M., Abad, M. J., Fernandez, L., Silvan, A. M., De Santos, J., Bermejo, P., Phenylpropanoid glycosides from Scrophularia scorodonia: In vitro antiinflammatory activity, Life Sciences, 2004, 74(20), 2515-2526.

Matsuda, H., Morikawa T., Managi H., Yoshikawa, M., Antiallergic principles from Alpinia galanga: Structural requirements of phenylpropanoids for inhibition of degranulation and release of TNF-alpha and IL-4 in RBL-2H3 cells, Bioorganic and Medicinal Chemistry Letters, 2003, 13(19), 3197-3202.

Cos, P., Rajan, P., Vedernikova, I., Calomme, M., Pieters, L., Vlietinck, A. J, In vitro antioxidant profile of phenolic acid derivatives, Free Radical Research, 2002, 36(6), 711–716.

Wong, I. Y. F., He, Z. D., Huang, Y., Chen, Z. Y., Antioxidative activities of phenylethanoid glycosides from Ligustrum purpurascens, Journal of Agricultural and Food Chemistry, 2001, 49(6), 3113-3119.

Downloads

Published

2023-09-05